Selected publications

Recent:

2023

Lopez-Otin C, Blasco M, Partridge L, Serrano M, Kroemer G. The hallmarks of cancer: An expanding universe. Cell. In press

Lopez-Otin C, Pietrola F, Galluzzi L, Kroemer G. Meta-hallmarks of aging and cancer. Cell Metab. In press

Hofer SJ, Simon AK, Bergmann M, Kroemer G , Madeo F. ( Corresponding author). Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging. In press

Montégut L, Joseph A, Chen H, Abdellatif M, Ruckenstuhl C, Martins I, Madeo F, Kroemer G. DBI/ACBP is a targetable pro-aging factor involved in autophagy inhibition and cardiovascular disease. Autophagy. In press

Ma Y, Kroemer G. The cancer-immune dialogue in the context of stress. Nat Rev Immunol. In press

Kroemer G, McQuade J, Merad M, André F, Zitvogel L. Bodywide ecological interventions on cancer. Nat Med. In press

2022

Montégut L, Joseph A, Chen H, Abdellatif M, Ruckenstuhl C, Motiño O, Lambertucci F, Anagnostopoulos G, Lachkar S, Dichtinger S, Maiuri MC, Goldwasser F, Blanchet B, Fumeron F, Martins I, Madeo F, Kroemer G. High plasma concentrations of acyl-coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP. Aging Cell. 2022 Dec 12:e13751.

Cardio-, hepato- and pneumoprotective effects of autophagy checkpoint inhibition by targeting DBI/ACBP. Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Martins I, Kroemer G. Autophagy. 2022 Oct 10:1-3. Online ahead of print.

Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, Martins I, Kroemer G. ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207344119.

Montégut L, de Cabo R, Zitvogel L, Kroemer G. Science-driven nutritional interventions for the prevention and treatment of cancer. Cancer Discov. 2022 2022 Oct 5;12(10):2258-2279.

Abdellatif M, Madeo F, Kroemer G , Sedej S. ( Corresponding author). Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart. Autophagy. 2022 Oct;18(10):2500-2502.

Juncheng P, Joseph A, Lafarge A, Martins I, Obrist F, Pol J, Saavedra E, Li S, Sauvat A, Cerrato G, Lévesque S, Leduc M, Kepp O, Durand S, Aprahamian F, Nirmalathansan N, Michels J, Kroemer G , Castedo M. ( Corresponding author). Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer. J Immunother Cancer. 2022 Jun;10(6):e004280

Zitvogel L, Kroemer G. Boosting the immunotherapy response by nutritional interventions. J Clin Invest. 2022 Jun 1;132(11):e161483

Abdellatif M, Trummer-Herbst V, Martin Heberle A, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J, Pittol JMR, Kepp O, Hoefler G, Schmidt A, Rainer PP, Scherr D, von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S. Fine-Tuning Cardiac Insulin/Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity. Circulation. 2022 Jun 21;145(25):1853-1866.

Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G , Kaufman RJ, Malhi H, Ren J. ( Corresponding author). Endoplasmic Reticulum Stress in Liver Diseases. Hepatology. 2022 May 6. doi: 10.1002/hep.32562.

Bezu L, Wu Chuang A, Sauvat A, Humeau J, Xie W, Cerrato G, Liu P, Zhao L, Zhang S, Le Naour J, Pol J, van Endert P, Kepp O, Barlesi F, Kroemer G. Local anesthetics elicit immune-dependent anticancer effects. J Immunother Cancer. 2022 Apr;10(4):e004151.

Kroemer G, Galassi C, Zitvogel L, Galluzzi L. Immunogenic cell stress and death. Nat Immunol. 2022 Apr;23(4):487-500.

Anagnostopoulos G, Motiño O, Li S, Carbonnier V, Chen H, Sica V, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Donne R, Desdouets C, Sola MS, Kotta K, Montégut L, Lambertucci F, Surdez D, Sandrine G, Delattre O, Maiuri MC, Bravo-SanPedro JM, Martins I, Kroemer G. An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor. Cell Death Dis. 2022 Apr 18;13(4):356.

Tang D, Chen X, Kroemer G. Cuproptosis: a copper-triggered modality of mitochondrial cell death. Cell Res. 2022 May;32(5):417-418.

Terrisse S, Goubet AG, Ueda K, Thomas AM, Quiniou V, Thelemaque C, Dunsmore G, Clave E, Gamat-Huber M, Yonekura S, Ferrere G, Rauber C, Pham HP, Fahrner JE, Pizzato E, Ly P, Fidelle M, Mazzenga M, Costa Silva CA, Armanini F, Pinto F, Asnicar F, Daillère R, Derosa L, Richard C, Blanchard P, Routy B, Culine S, Opolon P, Silvin A, Ginhoux F, Toubert A, Segata N, McNeel DG, Fizazi K, Kroemer G , Zitvogel L. (Corresponding author). Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer. J. Immunother Cancer. 2022 Mar;10(3):e004191.

Zitvogel L, Derosa L, Kroemer G. Modulation of cancer immunotherapy by dietary fibers and over-the-counter probiotics. Cell Metab. 2022 Mar 1;34(3):350-352.

Kroemer G, Galassi C, Zitvogel L, Galluzzi L. Immunogenic cell stress and death. Nat Immunol. 2022 Apr;23(4):487-500.

Anagnostopoulos G, Motiño O, Li S, Carbonnier V, Chen H, Sica V, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Donne R, Desdouets C, Sola MS, Kotta K, Montégut L, Lambertucci F, Surdez D, Sandrine G, Delattre O, Maiuri MC, Bravo-SanPedro JM, Martins I, Kroemer G. An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor. Cell Death Dis. 2022 Apr 18;13(4):356.

Montégut L, Chen H, Motiño O, Bravo San Pedro JM, Motiño O, Martins I and Kroemer G. Immunization of mice with the self-peptide ACBP coupled to keyhole limpet hemocyanin. STAR Protocols. 2022 March 18: 3(1):101095.

Zitvogel L, Kroemer G. Caloric restriction engages the microbiota to mediate anticancer effects. Nat Metab. In press

2021 

Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021 Nov 30;144(22):1795-1817.

Zitvogel L, Kroemer G. Bortezomib Induces Immunogenic Cell Death in Multiple Myeloma. Blood Cancer Discov. 2021 May 26;2(5):405-407.

Tang D, Kroemer G , Kang R. ( Corresponding author). Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges. Mol Cancer. 2021 Oct 4;20(1):128.

Paillet J, Plantureux C, Lévesque S, Le Naour J, Stoll G, Sauvat A, Caudana P, Tosello Boari J, Bloy N, Lachkar S, Martins I, Opolon P, Checcoli A, Delaune A, Robil N, de la Grange P, Hamroune J, Letourneur F, Autret G, Leung PSC, Gershwin ME, Zhu JS, Kurth MJ, Lekbaby B, Augustin J, Kim Y, Gujar S, Coulouarn C, Fouassier L, Zitvogel L, Piaggio E, Housset C, Soussan P, Maiuri MC, Kroemer G , Pol JG. ( Corresponding author). Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma. J Exp Med. 2021 Oct 4;218(10):e20200853.

Zhao L, Liu P, Xie W, Zhang S, Thieme S, Zitvogel L, Kroemer G , Kepp O. ( Corresponding author). A genotype-phenotype screening system using conditionally immortalized immature dendritic cells. STAR Protoc. 2021 Aug 12;2(3):100732.

Derosa L, Routy B, Desilets A, Daillère R, Terrisse S, Kroemer G, Zitvogel L. Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology? Cancer Discov. 2021 Oct;11(10):2396-2412.

Chen X, Zeh HJ, Kang R, Kroemer G , Tang D. ( Corresponding author). Cell death in pancreatic cancer: from pathogenesis to therapy. Nat Rev Gastroenterol Hepatol. 2021 Nov;18(11):804-823.

Petrazzuolo A, Perez-Lanzon M, Martins I, Liu P, Kepp O, Minard-Colin V, Maiuri MC, Kroemer G. Pharmacological inhibitors of anaplastic lymphoma kinase (ALK) induce immunogenic cell death through on-target effects. Cell Death Dis. 2021 Jul 16;12(8):713.

Joseph A, Juncheng P, Mondini M, Labaied N, Loi M, Adam J, Lafarge A, Astesana V, Obrist F, Klein C, Bloy N, Stoll G, Signolle N, Genestie C, Damotte D, Alifano M, Leary A, Pautier P, Morice P, Gouy S, Deutsch E, Chargari C, Dieu-Nosjean MC, Cremer I, Michels J, Kroemer G , Castedo M. ( Corresponding author). Metabolic features of cancer cells impact immunosurveillance. J Immunother Cancer. 2021 Jun;9(6):e002362.

Wu Q, Tian AL, Li B, Leduc M, Forveille S, Hamley P, Galloway W, Xie W, Liu P, Zhao L, Zhang S, Hui P, Madeo F, Tu Y, Kepp O, Kroemer G. IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J Immunother Cancer. 2021 Jun;9(6):e002722.

Kepp O, Bezu L, Yamazaki T, Di Virgilio F, Smyth MJ, Kroemer G , Galluzzi L. ( Corresponding author). ATP and cancer immunosurveillance. EMBO J. 2021 Jul 1;40(13):e108130.

Joseph A, Chen H, Anagnostopoulos G, Montégut L, Lafarge A, Motiño O, Castedo M, Maiuri MC, Clément K, Terrisse S, Martin AL, Vaz-Luis I, Andre F, Grundler F, de Toledo FW, Madeo F, Zitvogel L, Goldwasser F, Blanchet B, Fumeron F, Roussel R, Martins I, Kroemer G. Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index. Cell Death Dis. 2021 Jun 9;12(6):599.

Mittelbrunn M, Kroemer G. Hallmarks of T cell aging. Nat Immunol. 2021 Jun;22(6):687-698.

Chen X, Kang R, Kroemer G , Tang D. ( Corresponding author). Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021 Jun 7;218(6):e20210518.

Zitvogel L, Perreault C, Finn O, Kroemer G. Beneficial autoimmunity improves cancer prognosis. Nat Rev Clin Oncol. 2021 Sep;18(9):591-602.

Montégut L, Lopez-Otin C, Magnan C, Kroemer G. Old Paradoxes and New Opportunities for Appetite Control in Obesity. Trends Endocrinol Metab. 2021 May;32(5):264-294.

Kroemer G, Zitvogel L. Immune checkpoint inhibitors. J Exp Med. 2021 Mar 1;218(3):e20201979.

Abdellatif M, Trummer-Herbst V, Koser F, Durand S, Adão R, Vasques-Nóvoa F, Freundt JK, Voglhuber J, Pricolo MR, Kasa M, Türk C, Aprahamian F, Herrero-Galán E, Hofer SJ, Pendl T, Rech L, Kargl J, Anto-Michel N, Ljubojevic-Holzer S, Schipke J, Brandenberger C, Auer M, Schreiber R, Koyani CN, Heinemann A, Zirlik A, Schmidt A, von Lewinski D, Scherr D, Rainer PP, von Maltzahn J, Mühlfeld C, Krüger M, Frank S, Madeo F, Eisenberg T, Prokesch A, Leite-Moreira AF, Lourenço AP, Alegre-Cebollada J, Kiechl S, Linke WA, Kroemer G , Sedej S. (Corresponding author). Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci Transl Med. 2021 Feb 10;13(580):eabd7064.

Zitvogel L, Kroemer G. Lower Airway Dysbiosis Exacerbates Lung Cancer. Cancer Discov. 2021 Feb;11(2):224-226.

Chen X, Kang R, Kroemer G , Tang D (Corresponding author). Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021 May;18(5):280-296.

Liu J, Song X, Kuang F, Zhang Q, Xie Y, Kang R, Kroemer G , Tang D. ( Corresponding author). NUPR1 is a critical repressor of ferroptosis. Nat Commun. 2021 Jan 28;12(1):647.

Cerrato G, Leduc M, Müller K, Humeau J, Kepp O, Sauvat A, Kroemer G. Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade. Cell Death Differ. 2021 May;28(5):1733-1752.

Ferrere G, Tidjani Alou M, Liu P, Goubet AG, Fidelle M, Kepp O, Durand S, Iebba V, Fluckiger A, Daillère R, Thelemaque C, Grajeda-Iglesias C, Alves Costa Silva C, Aprahamian F, Lefevre D, Zhao L, Ryffel B, Colomba E, Arnedos M, Drubay D, Rauber C, Raoult D, Asnicar F, Spector T, Segata N, Derosa L, Kroemer G , Zitvogel L. ( Corresponding author). Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. JCI Insight. 2021 Jan 25;6(2):145207.

Kroemer G, Zitvogel L. Subversion of calreticulin exposure as a strategy of immune escape. Cancer Cell. 2021 Apr 12;39(4):449-451.

López-Otín C, Kroemer G. Hallmarks of Health. Cell. 2021 Jan 7;184(1):33-63.

Yamazaki T, Bravo-San Pedro JM, Galluzzi L, Kroemer G , Pietrocola F. ( Corresponding author). Autophagy in the cancer-immunity dialogue. Adv Drug Deliv Rev. 2021 Feb;169:40-50.

Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021 Feb;31(2):107-125.

Le Naour J, Liu P, Zhao L, Adjemian S, Sztupinszki Z, Taieb J, Mulot C, Silvin A, Dutertre CA, Ginhoux F, Sauvat A, Cerrato G, Castoldi F, Martins I, Stoll G, Paillet J, Mangane K, Richter C, Kepp O, Maiuri MC, Pietrocola F, Vandenabeele P, André F, Delaloge S, Szallasi Z, Laurent-Puig P, Zucman-Rossi J, Zitvogel L, Pol JG, Vacchelli E, Kroemer G. A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency. Cancer Discov. 2021 Feb;11(2):408-423.

Fucikova J, Spisek R, Kroemer G , Galluzzi L (Corresponding author). Calreticulin and cancer. Cell Res. 2021 Jan;31(1):5-16.

Petroni G, Buqué A, Zitvogel L, Kroemer G , Galluzzi L. ( Corresponding author). Immunomodulation by targeted anticancer agents. Cancer Cell. 2021 Mar 8;39(3):310-345.

Among more than 1000 scientific publications. For a full list please check here.